"We Takin' Over" is the first single from DJ Khaled's second album, We the Best. Akon, T.I., Rick Ross, Fat Joe, Birdman and Lil Wayne are all featured on this track. Nate "Danja" Hills assisted the artists in writing the song and is also the producer. The song was released through the iTunes Store on March 27, 2007 and debuted at number 51 on Billboard's Hot R&B/Hip-Hop Songs chart and has peaked at number 26. It debuted on the Billboard Hot 100 on the issue date of April 14, 2007 at number 75, and has peaked at 28.
Cameos in the video are made by Pitbull, Junior Reid, DJ Infamous, Freeway, Triple C's, Johnny Dang, T-Pain, Trina, Curren$y, and Cool & Dre among others. The video has many similarities to The Notorious B.I.G.'s video for "Hypnotize". The video was directed by Gil Green.